Polaris Peptides retatrutide: all five strengths compared
Polaris Peptides retatrutide comes in five strengths, from a 5mg vial at $50 to a 60mg vial for long studies. This guide covers what retatrutide is, what the trials found and how to pick a vial.
What is Polaris Peptides retatrutide?
Retatrutide (LY3437943) is a single peptide from Eli Lilly that activates three hormone receptors at once: GIP, GLP-1 and glucagon. That makes it a triple agonist, one step beyond tirzepatide, which hits two. A fatty acid side chain lets it bind albumin in blood, so it lasts long enough for once-weekly study.
Polaris Peptides retatrutide is sold as freeze-dried powder in vacuum-sealed vials, tested by HPLC-MS at over 99% purity. It’s for laboratory research only.
Polaris Peptides retatrutide prices
- Retatrutide 5mg: from $50 (on sale)
- Retatrutide 10mg: from $89 (on sale)
- Retatrutide 15mg: from $130 (on sale)
- Retatrutide 35mg: from $275 (on sale)
- Retatrutide 60mg: from $400
Bigger vials cost less per milligram. The 5mg vial works out to about $10 per mg, while the 60mg vial comes to about $6.67. Several strengths are on sale right now, and every one comes in packs of up to 20 vials. A 20-pack of retatrutide 10mg brings the price to about $62.30 a vial.
What the retatrutide research found
The phase 2 obesity trial, published in the New England Journal of Medicine in 2023 by Jastreboff and colleagues, reported average weight reductions of up to about 24% after 48 weeks at the highest dose. That was the largest figure reported for any incretin drug at the time. A separate phase 2 trial looked at people with type 2 diabetes.
Lilly’s phase 3 program, called TRIUMPH, is testing retatrutide in obesity, knee osteoarthritis and sleep apnea. You can follow the trials on ClinicalTrials.gov and read the published papers through this PubMed search for retatrutide.
How retatrutide works
GLP-1 activity slows stomach emptying and reduces appetite. GIP adds to insulin release and seems to improve how fat tissue handles energy. Glucagon is the unusual one: in the liver it raises energy use and fat burning, which is why labs study retatrutide for liver fat as well as body weight.
Choosing a Polaris Peptides retatrutide vial
For a pilot run, retatrutide 5mg keeps the cost down. Most studies settle on 10mg or 15mg. For long projects, 35mg and 60mg mean fewer vials to mix and the lowest price per milligram.
Mixing and storing retatrutide
Add sterile bacteriostatic water slowly down the inside of the vial and swirl gently until it’s clear. A 10mg vial with 2mL gives 5mg/mL. Keep sealed vials in a freezer at -20°C. Once mixed, keep the vial in the fridge at 2 to 8°C and use it within 28 days.
Polaris Peptides retatrutide specifications
- Compound: retatrutide (LY3437943)
- Type: GIP, GLP-1 and glucagon receptor triple agonist
- Strengths: 5mg, 10mg, 15mg, 35mg and 60mg per vial
- Form: lyophilized (freeze-dried) powder, vacuum-sealed
- Purity: over 99% by HPLC-MS
- Packs: 2, 5, 10, 15 and 20 vials, 10% to 30% off
- Use: laboratory research only
Retatrutide compared with tirzepatide and semaglutide
The three GLP-1 compounds in our range differ by how many receptors they reach. Semaglutide acts on GLP-1 alone. Tirzepatide adds GIP. Retatrutide adds glucagon on top of both. In published trials, each added receptor came with a larger average drop in body weight, though the trials weren’t run head to head.
That’s why labs often order two or three of them together: one compound per arm, the same model, and a clean comparison of single, dual and triple agonism. Polaris Peptides retatrutide sits at the top of that ladder.
Calculating retatrutide concentrations
- 5mg vial + 1mL water = 5mg/mL
- 10mg vial + 2mL water = 5mg/mL
- 15mg vial + 3mL water = 5mg/mL
- 35mg vial + 3.5mL water = 10mg/mL
- 60mg vial + 6mL water = 10mg/mL
Keeping every vial at the same concentration makes it much easier to switch strengths partway through a project. Write the concentration and mixing date on the label.
Polaris Peptides retatrutide picks at a glance
Retatrutide 5mg
Retatrutide 15mg
Retatrutide 35mg
Retatrutide 60mgPolaris Peptides retatrutide FAQ
Which Polaris Peptides retatrutide strengths are there?
Five: 5mg, 10mg, 15mg, 35mg and 60mg, each as freeze-dried powder in a vacuum-sealed vial.
Which retatrutide vial is cheapest per milligram?
The 60mg vial, at about $6.67 per mg against $10 for the 5mg.
Is retatrutide approved?
No. It’s still in phase 3 trials and isn’t approved anywhere. Ours is sold for laboratory research only.
Can I buy retatrutide in bulk?
Yes. Every strength comes in packs of 2 to 20 vials, saving 10% to 30% per vial.
Related reading: Polaris Peptides tirzepatide, Polaris Peptides semaglutide and the full GLP-1 peptides range.
Buy retatrutide from Polaris Peptides
Five strengths, over 99% pure and in stock, with bulk packs up to 30% off.
Polaris Peptides products are sold for laboratory research use only. They aren’t for human or veterinary use and haven’t been evaluated by the FDA.