Retatrutide 60mg

Description

Retatrutide 60mg from Polaris Peptides is 60mg of Retatrutide in a sealed glass vial. Retatrutide is a GIP, GLP-1 and glucagon receptor agonist. It’s intended for lab research only.

What is Retatrutide?

Retatrutide (LY3437943, often sold as GLP-3R) is a single peptide from Eli Lilly that acts on three receptors: GIP, GLP-1 and glucagon.

It’s still in clinical trials.

Retatrutide mechanism of action

Retatrutide hits three receptors with one peptide: GIP, GLP-1 and glucagon. The first two are incretins that boost glucose-dependent insulin release and, in GLP-1’s case, curb appetite and slow stomach emptying.

The glucagon part is the unusual bit. Glucagon raises energy expenditure and pushes the liver to burn fat, so pairing it with the incretins is meant to work on both sides of energy balance. That’s the main reason researchers compare it with the dual and single agonists.

Retatrutide 60mg product details

• Compound: Retatrutide
• Also known as: LY3437943
• CAS number: 2381089-83-2
• Molar mass: 4,731.3 g/mol
• Structure: 39 amino acids with a fatty diacid side chain
• Amount: 60mg per vial
• Form: lyophilized (freeze-dried) powder
• Purity: over 99% (HPLC-MS)
• Packaging: vacuum-sealed
• SKU: PP-RETA-60
• Use: laboratory research only

Retatrutide research

Jastreboff and colleagues reported in the New England Journal of Medicine (2023) a mean weight loss of up to 24% at 48 weeks in a phase 2 trial.

Phase 3 trials are under way.

The primary literature is on PubMed. Here’s a search for Retatrutide studies to start from.

Retatrutide 60mg vs related compounds

Here’s how Retatrutide 60mg fits among related compounds. Retatrutide hits GLP-1, GIP and glucagon receptors, the triple agonist with the biggest phase 2 numbers so far. By comparison:

• Semaglutide acts on the GLP-1 receptor only and lasts about a week, the most studied compound in the group
• Tirzepatide adds GIP receptor activity to GLP-1, a dual agonist with larger weight effects than semaglutide in trials
• Cagrilintide works through amylin receptors instead of incretins, often studied next to or with semaglutide
• Survodutide pairs GLP-1 with glucagon receptor activity, studied for liver fat as well as weight
• Mazdutide is an oxyntomodulin-style GLP-1 and glucagon dual agonist, approved in China in 2025

The main difference between these compounds is which receptors they hit. Pick the one that matches the receptor question in your study, and use the others as comparisons. See them all on our GLP-1 peptides page.

How Retatrutide 60mg is tested

We test Retatrutide 60mg by HPLC-MS, which pairs liquid chromatography with mass spectrometry. The first part measures purity and the second confirms the molecule is the right one. Retatrutide 60mg tests at over 99% purity.

After freeze-drying, each vial is vacuum-sealed. Keeping air and moisture out is what lets lyophilized peptide stay stable for months in a freezer.

Write the batch number from the label into your lab notes. If a result looks odd later, you can tie it back to the exact batch you used.

Reconstituting Retatrutide 60mg

Concentration is the amount in the vial divided by the volume of water you add. With 60mg of powder in this vial:

• 2mL of bacteriostatic water gives 30mg/mL
• 3mL of bacteriostatic water gives 20mg/mL
• 5mL of bacteriostatic water gives 12mg/mL

Pick the volume that keeps your own calculations simple, then write the concentration and the mixing date on the label.

Bacteriostatic water is the usual choice. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.

Storing Retatrutide 60mg

Freeze-dried Retatrutide 60mg handles room temperature fine during shipping, but for anything longer keep it in a freezer at -20°C, away from light. Once mixed, keep it in the fridge at 2 to 8°C and use it within 28 days.

Let a frozen vial warm up to room temperature before you open it. Cold glass pulls moisture out of the air, and that moisture is what degrades dry peptide.

Choosing a Retatrutide strength

• Retatrutide 5mg: $50.00, about $10.00 per mg
• Retatrutide 10mg: $89.00, about $8.90 per mg
• Retatrutide 15mg: $130.00, about $8.67 per mg
• Retatrutide 35mg: $275.00, about $7.86 per mg
• Retatrutide 60mg (this page): $400.00, about $6.67 per mg

Retatrutide 60mg is one of the larger sizes, and bigger vials usually cost less per milligram. It suits longer studies where you’d otherwise reorder.

Save on Retatrutide 60mg in bulk

Pick a quantity from the menu above the cart button. The more vials you order, the lower the price of each one:

• 1 vial: $400.00
• 2 vials: $720.00, about $360.00 per vial (save 10%)
• 5 vials: $1,700.00, about $340.00 per vial (save 15%)
• 10 vials: $3,080.00, about $308.00 per vial (save 23%)
• 15 vials: $4,440.00, about $296.00 per vial (save 26%)
• 20 vials: $5,600.00, about $280.00 per vial (save 30%)

The 20-vial pack brings the price down by 30%. Packs ship as individual sealed vials, so you only open what you need.

Related to Retatrutide 60mg

• Mazdutide 6mg, a GLP-1/glucagon agonist
• Semaglutide 20mg, a GLP-1 agonist
• Tirzepatide 5mg, a GIP/GLP-1 agonist
• Survodutide 5mg, a GLP-1/glucagon agonist
• Cagrilintide Semaglutide Blend 10mg/10mg, Cagrilintide and Semaglutide in one vial

Browse the full GLP-1 peptides and weight loss peptides range, or see every product on our research peptides page.

Retatrutide 60mg FAQ

How much is in the Retatrutide 60mg vial?

60mg of freeze-dried powder. The amount is printed on the label.

Is there a bulk discount?

Yes. Choose 2, 5, 10, 15 and 20 vials in the Quantity menu and save between 10% and 30% per vial.

How pure is Retatrutide 60mg?

Over 99% by HPLC-MS. The same test confirms the molecular weight, so it checks identity too.

What do I mix Retatrutide 60mg with?

Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.

How should I store it?

Keep sealed vials in the freezer at -20°C. Once mixed, refrigerate at 2 to 8°C and use within 28 days.

Buy Retatrutide 60mg online

Order Retatrutide 60mg now for $400.00. It’s in stock, and checkout takes about two minutes. Ordering more? Packs of up to 20 save up to 30%.

Need more for the same project? See the rest of our GLP-1 peptides and weight loss peptides.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.